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Article

Splicing factors facilitate RNAi-directed silencing in fission yeast.

Science (New York, N.Y.) - 24 Oct 2008

Bayne Elizabeth H, Portoso Manuela, Kagansky Alexander, Kos-Braun Isabelle C, Urano Takeshi, Ekwall Karl, Alves Flavia, Rappsilber Juri, Allshire Robin C

Abstract excerpt

Heterochromatin formation at fission yeast centromeres is directed by RNA interference (RNAi). Noncoding transcripts derived from centromeric repeats are processed into small interfering RNAs (siRNAs) that direct the RNA-induced transcriptional silencing (RITS) effector complex to engage centromere transcripts, resulting in recruitment of the histone H3 lysine 9 methyltransferase Clr4, and hence silencing. We...

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Identifiers

PMID: 18948543
DOI: 10.1126/science.1164029
PMCID: PMC2585287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Splicing factors facilitate RNAi-directed silencing in fission yeast.PMID 18948543Read ↗

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Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA.Semantic proximity Read ↗

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.Semantic proximity Read ↗

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.Semantic proximity Read ↗

Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.Semantic proximity Read ↗

Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi.Semantic proximity Read ↗

RNAi-mediated targeting of heterochromatin by the RITS complex.Semantic proximity Read ↗

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.Semantic proximity Read ↗

Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.Semantic proximity Read ↗

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