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Article

Dicer independent small RNAs associate with telomeric heterochromatin

21 May 2009

Abstract excerpt

Small RNAs play important roles in the establishment and maintenance of heterochromatin structures. We show the presence of telomere specific small RNAs (tel-sRNAs) in mouse embryonic stem cells that are approximately 24 nucleotides in length, Dicer-independent, and 2'-O-methylated at the 3' terminus. The tel-sRNAs are asymmetric with specificity toward telomere G-rich strand, and evolutionarily conserved from...

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Share to Chromosomal and Genetic Variations
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PMID: 19460867
DOI: 10.1261/rna.1423309

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