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Article

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.

Molecular and cellular biology - 1 Sept 2008

Milligan Laura, Decourty Laurence, Saveanu Cosmin, Rappsilber Juri, Ceulemans Hugo, Jacquier Alain, Tollervey David

Abstract excerpt

A genome-wide screen for synthetic lethal (SL) interactions with loss of the nuclear exosome cofactors Rrp47/Lrp1 or Air1 identified 3'-->5' exonucleases, the THO complex required for mRNP assembly, and Ynr024w (Mpp6). SL interactions with mpp6Delta were confirmed for rrp47Delta and nuclear exosome component Rrp6. The results of bioinformatic analyses revealed homology between Mpp6 and a human exosome cofactor,...

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Identifiers

PMID: 18591258
DOI: 10.1128/MCB.00463-08
PMCID: PMC2519741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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