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Article

Bivariate association analysis in selected samples: application to a GWAS of two bone mineral density phenotypes in males with high or low BMD.

European journal of human genetics : EJHG - 1 Jun 2011

Saint-Pierre Aude, Kaufman Jean-Marc, Ostertag Agnes, Cohen-Solal Martine, Boland Anne, Toye Kaatje, Zelenika Diana, Lathrop Mark, de Vernejoul Marie-Christine, Martinez Maria

Abstract excerpt

Our specific aims were to evaluate the power of bivariate analysis and to compare its performance with traditional univariate analysis in samples of unrelated subjects under varying sampling selection designs. Bivariate association analysis was based on the seemingly unrelated regression (SUR) model that allows different genetic models for different traits. We conducted extensive simulations for the case of two...

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Identifiers

PMID: 21427758
DOI: 10.1038/ejhg.2011.22
PMCID: PMC3110051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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