Article
Optimal selection of sib pairs from random samples for linkage analysis of a QTL using the EDAC test.
Behavior genetics - 1 May 1998
Dolan C V, Boomsma D I
Abstract excerpt
Percentages of extremely concordant and extremely discordant sib pairs are calculated that maximize the power to detect a quantitative trait locus (QTL) under a variety of circumstances using the EDAC test. We assume a large fixed number of randomly sampled sib pairs, such as one would hope to find in the large twin registries, and limited resources to genotype a certain number of selected sib pairs. Our aim is...
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