A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes.

Abstract excerpt

Searching for genetic variants involved in gene-gene and gene-environment interactions in large-scale data raises multiple methodological issues. Many existing methods have focused on the problem of dimensionality, trying to explore the largest number of combinations between risk factors while considering simple interaction models. Despite evidence demonstrating the efficacy of these methods in simulated data,...

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