Article
Genetic Correlation, Shared Loci, and Causal Association Between Sex Hormone-Binding Globulin and Bone Mineral Density: Insights From a Large-Scale Genomewide Cross-Trait Analysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2023
Qu Yang, Xiao Changfeng, Wu Xueyao, Zhu Jingwei, Qin Chenjiarui, He Lin, Cui Huijie, Zhang Li, Zhang Wenqiang, Yang Chunxia, Yao Yuqin, Li Jiayuan, Liu Zhenmi, Zhang Ben, Wang Wenzhi, Jiang Xia
Abstract excerpt
Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary modulator, sex hormone-binding globulin (SHBG), remains inconclusive. This study aims to elucidate the genetic overlap between SHBG and heel estimated bone mineral density (eBMD), a widely-accepted tool for osteoporosis management and fracture risk assessment. Using summary statistics from large-scale genomewide...
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