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Article

Gene-level association analysis of bivariate ordinal traits with functional regressions.

Genetic epidemiology - 1 Sept 2023

Wang Shuqi, Chiu Chi-Yang, Wilson Alexander F, Bailey-Wilson Joan E, Agron Elvira, Chew Emily Y, Ahn Jaeil, Xiong Momiao, Fan Ruzong

Abstract excerpt

In genetic studies, many phenotypes have multiple naturally ordered discrete values. The phenotypes can be correlated with each other. If multiple correlated ordinal traits are analyzed simultaneously, the power of analysis may increase significantly while the false positives can be controlled well. In this study, we propose bivariate functional ordinal linear regression (BFOLR) models using latent regressions...

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Identifiers

PMID: 37101379
DOI: 10.1002/gepi.22524
PMCID: PMC13452082

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ARMS2
CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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