Article
Assessment of gene-by-sex interaction effect on bone mineral density.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2012
Liu Ching-Ti, Estrada Karol, Yerges-Armstrong Laura M, Amin Najaf, Evangelou Evangelos, Li Guo, Minster Ryan L, Carless Melanie A, Kammerer Candace M, Oei Ling, Zhou Yanhua, Alonso Nerea, Dailiana Zoe, Eriksson Joel, García-Giralt Natalia, Giroux Sylvie, Husted Lise Bjerre, Khusainova Rita I, Koromila Theodora, Kung Annie Waichee, Lewis Joshua R, Masi Laura, Mencej-Bedrac Simona, Nogues Xavier, Patel Millan S, Prezelj Janez, Richards J Brent, Sham Pak Chung, Spector Timothy, Vandenput Liesbeth, Xiao Su-Mei, Zheng Hou-Feng, Zhu Kun, Balcells Susana, Brandi Maria Luisa, Frost Morten, Goltzman David, González-Macías Jesús, Karlsson Magnus, Khusnutdinova Elza K, Kollia Panagoula, Langdahl Bente Lomholt, Ljunggren Osten, Lorentzon Mattias, Marc Janja, Mellström Dan, Ohlsson Claes, Olmos José M, Ralston Stuart H, Riancho José A, Rousseau François, Urreizti Roser, Van Hul Wim, Zarrabeitia María T, Castano-Betancourt Martha, Demissie Serkalem, Grundberg Elin, Herrera Lizbeth, Kwan Tony, Medina-Gómez Carolina, Pastinen Tomi, Sigurdsson Gunnar, Thorleifsson Gudmar, Vanmeurs Joyce Bj, Blangero John, Hofman Albert, Liu Yongmei, Mitchell Braxton D, O'Connell Jeffrey R, Oostra Ben A, Rotter Jerome I, Stefansson Kari, Streeten Elizabeth A, Styrkarsdottir Unnur, Thorsteinsdottir Unnur, Tylavsky Frances A, Uitterlinden Andre, Cauley Jane A, Harris Tamara B, Ioannidis John Pa, Psaty Bruce M, Robbins John A, Zillikens M Carola, Vanduijn Cornelia M, Prince Richard L, Karasik David, Rivadeneira Fernando, Kiel Douglas P, Cupples L Adrienne, Hsu Yi-Hsiang
Abstract excerpt
Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an...
