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Article

Complex segregation analysis accounting for GxE of bone mineral density in European pedigrees selected through a male proband with low BMD.

Annals of human genetics - 1 Jan 2007

Pelat C, Van Pottelbergh I, Cohen-Solal M, Ostertag A, Kaufman J-M, Martinez M, de Vernejoul M-C

Abstract excerpt

Osteoporosis is a common multifactorial disorder characterized by low bone mass (BMD) and high susceptibility to low-trauma fractures. Family and twin studies have found a strong genetic component in the determination of BMD, but the mode of inheritance of this trait is not yet fully understood. BMD is a complex trait whose expression is confounded by environmental influences and polygenic inheritance. Detection...

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Identifiers

PMID: 17227475
DOI: 10.1111/j.1469-1809.2006.00295.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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