Article
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
PloS one - 1 Jan 2015
Reppe Sjur, Wang Yunpeng, Thompson Wesley K, McEvoy Linda K, Schork Andrew J, Zuber Verena, LeBlanc Marissa, Bettella Francesco, Mills Ian G, Desikan Rahul S, Djurovic Srdjan, Gautvik Kaare M, Dale Anders M, Andreassen Ole A
Abstract excerpt
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide...
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