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Bivariate genome-wide association analyses identified genetic pleiotropic effects for bone mineral density and alcohol drinking in Caucasians.

Journal of bone and mineral metabolism - 1 Nov 2017

Lu Shan, Zhao Lan-Juan, Chen Xiang-Ding, Papasian Christopher J, Wu Ke-Hao, Tan Li-Jun, Wang Zhuo-Er, Pei Yu-Fang, Tian Qing, Deng Hong-Wen

Abstract excerpt

Several studies indicated bone mineral density (BMD) and alcohol intake might share common genetic factors. The study aimed to explore potential SNPs/genes related to both phenotypes in US Caucasians at the genome-wide level. A bivariate genome-wide association study (GWAS) was performed in 2069 unrelated participants. Regular drinking was graded as 1, 2, 3, 4, 5, or 6, representing drinking alcohol never, less...

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Alcohol Drinking
Bone Density
Genetic Pleiotropy
Genome-Wide Association Study
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 28012008
DOI: 10.1007/s00774-016-0802-7
PMCID: PMC5812284

Genes

GRIK4
OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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