Article
Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Sept 2020
Zhang H, Liu L, Ni J-J, Wei X-T, Feng G-J, Yang X-L, Xu Q, Zhang Z-J, Hai R, Tian Q, Shen H, Deng H-W, Pei Y-F, Zhang L
Abstract excerpt
Aiming to identify pleiotropic genomic loci for bone mineral density and bone size, we performed a bivariate GWAS in five discovery samples and replicated in two large-scale samples. We identified 2 novel loci at 2q37.1 and 6q26. Our findings provide insight into common genetic architecture underlying both traits. INTRODUCTION: Bone mineral density (BMD) and bone size (BS) are two important factors that...
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