Bivariate association analysis for quantitative traits using generalized estimation equation.

doi:10.1016/S1673-8527(08)60166-6

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Article

Bivariate association analysis for quantitative traits using generalized estimation equation.

Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2009

Yang Fang, Tang Zihui, Deng Hongwen

Abstract excerpt

Quantitative traits often underlie risk for complex diseases. Many studies collect multiple correlated quantitative phenotypes and perform univariate analyses on each of them respectively. However, this strategy may not be powerful and has limitations to detect pleiotropic genes that may underlie correlated quantitative traits. In addition, testing multiple traits individually will exacerbate perplexing problem...

Topics

Algorithms
Computational Biology
Computer Simulation
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Markov Chains
Models, Genetic
Monte Carlo Method
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Sample Size
Software
Statistics as Topic

Source

Open in PubMed

Identifiers

PMID: 20129400
DOI: 10.1016/S1673-8527(08)60166-6

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