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Article

IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis C

22 Aug 2010

Abstract excerpt

UNLABELLED: Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon-α and ribavirin. We hypothesized that IL28B polymorphism is associated with intrahepatic expression of interferon-stimulated genes (ISGs), known to influence treatment outcome....

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PMID: 20931559
DOI: 10.1002/hep.23912

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Related research

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Research trail→

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IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis CPMID 20931559Read ↗

Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.Semantic proximity Read ↗

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Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype.Semantic proximity Read ↗

Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes.Semantic proximity Read ↗

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Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.Semantic proximity Read ↗

Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.Semantic proximity Read ↗

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IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.Semantic proximity Read ↗

Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients.Semantic proximity Read ↗

Genetic variants of interferon-stimulated genes and IL-28B as host prognostic factors of response to combination treatment for chronic hepatitis C.Semantic proximity Read ↗

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