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Article

IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.

Journal of hepatology - 1 Jun 2011

Abe Hiromi, Hayes C Nelson, Ochi Hidenori, Maekawa Toshiro, Tsuge Masataka, Miki Daiki, Mitsui Fukiko, Hiraga Nobuhiko, Imamura Michio, Takahashi Shoichi, Kubo Michiaki, Nakamura Yusuke, Chayama Kazuaki

Abstract excerpt

BACKGROUND & AIMS: Common genetic variation within the IL28 locus has been found to influence the effect of peg-interferon and ribavirin combination therapy against chronic hepatitis C virus (HCV) infection. Expression of IL28 in peripheral blood cells has been reported to be higher in patients w...

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Source

Identifiers

PMID: 21145800
DOI: 10.1016/j.jhep.2010.09.019

Genes

ISG15
OAS1
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21145800-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.PMID 21145800Read ↗

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Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.Semantic proximity Read ↗

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Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients.Semantic proximity Read ↗

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