Article
Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.
Journal of gastroenterology and hepatology - 1 Jun 2015
Murakawa Miyako, Asahina Yasuhiro, Nakagawa Mina, Sakamoto Naoya, Nitta Sayuri, Kusano-Kitazume Akiko, Watanabe Takako, Kawai-Kitahata Fukiko, Otani Satoshi, Taniguchi Miki, Goto Fumio, Nishimura-Sakurai Yuki, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Watanabe Mamoru
Abstract excerpt
BACKGROUND AND AIM: Interferon (IFN) λ plays an important role in innate immunity to protect against hepatitis C viral (HCV) infection. Single nucleotide polymorphisms (SNPs) near IL28B (IFNλ3) are strongly associated with treatment response to IFNα therapy in chronic hepatitis C (CHC) patients. Recently, IFNλ4 related to IL28B-unfavorable allele was discovered. However, the impact of IFNλs on CHC is unknown. We...
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