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Article

Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.

Gastroenterology - 1 Aug 2010

Honda Masao, Sakai Akito, Yamashita Tatsuya, Nakamoto Yasunari, Mizukoshi Eishiro, Sakai Yoshio, Yamashita Taro, Nakamura Mikiko, Shirasaki Takayoshi, Horimoto Katsuhisa, Tanaka Yasuhito, Tokunaga Katsushi, Mizokami Masashi, Kaneko Shuichi

Abstract excerpt

BACKGROUND & AIMS: Multiple viral and host factors are related to the treatment response to pegylated-interferon and ribavirin combination therapy; however, the clinical relevance and relationship of these factors have not yet been fully evaluated. METHODS: We studied 168 patients with chronic hepatitis C who received pegylated-interferon and ribavirin combination therapy. Gene expression profiles in the livers...

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Identifiers

PMID: 20434452
DOI: 10.1053/j.gastro.2010.04.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.PMID 20434452Read ↗

Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.Semantic proximity Read ↗

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Genetic variants of interferon-stimulated genes and IL-28B as host prognostic factors of response to combination treatment for chronic hepatitis C.Semantic proximity Read ↗

[IL28B genetic variation and hepatic ISGs expression predict treatment efficacy of IFN-based anti-viral therapy for chronic hepatitis C].Semantic proximity Read ↗

Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes.Semantic proximity Read ↗

Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.Semantic proximity Read ↗

Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients.Semantic proximity Read ↗

Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.Semantic proximity Read ↗

Host genomics and HCV treatment response.Semantic proximity Read ↗

Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype.Semantic proximity Read ↗

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