Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.

Gastroenterology - 1 Mar 2011

Dill Michael T, Duong Francois H T, Vogt Julia E, Bibert Stéphanie, Bochud Pierre-Yves, Terracciano Luigi, Papassotiropoulos Andreas, Roth Volker, Heim Markus H

Abstract excerpt

BACKGROUND & AIMS: The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with nonresponse to pegylated IFN-α (pegIFN-α) and ribavirin. Genome-wide association studies have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Decision Support Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decision Trees

Share to Interferon alpha-2

Share to Oxidoreductases Acting on CH-CH Group Donors

Share to Polyethylene Glycols

Share to Switzerland

Share to Ubiquitins

Source

Identifiers

PMID: 21111740
DOI: 10.1053/j.gastro.2010.11.039

Genes

HTATIP2
IFI27
ISG15
RSAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.PMID 21111740Read ↗

Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.Semantic proximity Read ↗

IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis CSemantic proximity Read ↗

IL28B genotype and the expression of ISGs in normal liver.Semantic proximity Read ↗

Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients.Semantic proximity Read ↗

Genetic variants of interferon-stimulated genes and IL-28B as host prognostic factors of response to combination treatment for chronic hepatitis C.Semantic proximity Read ↗

Hepatic expression levels of interferons and interferon-stimulated genes in patients with chronic hepatitis C: A phenotype-genotype correlation study.Semantic proximity Read ↗

Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection.Semantic proximity Read ↗

Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.Semantic proximity Read ↗

An interferon response gene signature is associated with the therapeutic response of hepatitis C patients.Semantic proximity Read ↗

Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes.Semantic proximity Read ↗

The Interferon Signaling Pathway Genes as Biomarkers of Hepatitis C Virus Disease Progression and Response to TreatmentSemantic proximity Read ↗

The Impact of IL28B Genotype and Liver Fibrosis on the Hepatic Expression of IP10, IFI27, ISG15, and MX1 and Their Association with Treatment Outcomes in Patients with Chronic Hepatitis C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.