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Article

Genetic variants of interferon-stimulated genes and IL-28B as host prognostic factors of response to combination treatment for chronic hepatitis C.

Clinical pharmacology and therapeutics - 1 Nov 2011

Lopez-Rodriguez R, Trapero-Marugan M, Borque M J, Roman M, Hernandez-Bartolome A, Rodriguez-Muñoz Y, Martin-Vilchez S, Abad-Santos F, Muñoz de Rueda P, Vidal-Castiñeira J R, Rodrigo L, Salmeron J, Moreno-Otero R, Sanz-Cameno P

Abstract excerpt

Chronic hepatitis C (CHC) is a worldwide health problem that is highly related to liver fibrosis, cirrhosis, and hepatocellular carcinoma. The achievement of response to the current standard of care-pegylated interferon plus ribavirin-has recently been described to be associated with single-nucleotide polymorphisms (SNPs) near the IL-28B gene. Additionally, baseline expression levels of genes involved in...

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PMID: 21993426
DOI: 10.1038/clpt.2011.189

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Genetic variants of interferon-stimulated genes and IL-28B as host prognostic factors of response to combination treatment for chronic hepatitis C.PMID 21993426Read ↗

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