Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

doi:10.1053/j.gastro.2009.12.056

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Article

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

Gastroenterology - 1 Apr 2010

Rauch Andri, Kutalik Zoltán, Descombes Patrick, Cai Tao, Di Iulio Julia, Mueller Tobias, Bochud Murielle, Battegay Manuel, Bernasconi Enos, Borovicka Jan, Colombo Sara, Cerny Andreas, Dufour Jean-François, Furrer Hansjakob, Günthard Huldrych F, Heim Markus, Hirschel Bernard, Malinverni Raffaele, Moradpour Darius, Müllhaupt Beat, Witteck Andrea, Beckmann Jacques S, Berg Thomas, Bergmann Sven, Negro Francesco, Telenti Amalio, Bochud Pierre-Yves

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy. METHODS: The analysis included 1362 individuals: 1015 with chronic hepatitis C and 347 who spontaneously cleared the virus (448...

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PMID: 20060832
DOI: 10.1053/j.gastro.2009.12.056

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