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Article

Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.

Journal of medical virology - 1 Sept 2011

Abe Hiromi, Hayes C Nelson, Ochi Hidenori, Tsuge Masataka, Miki Daiki, Hiraga Nobuhiko, Imamura Michio, Takahashi Shoichi, Kubo Michiaki, Nakamura Yusuke, Kamatani Naoyuki, Chayama Kazuaki

Abstract excerpt

High intrahepatic expression levels of interferon stimulated genes (ISGs) in chronic hepatitis C patients are associated with poor response to interferon plus ribavirin combination therapy. Expression levels of 16 genes (OAS1, PKR, MxA, ISG15, RIG-I, TLR8, IRF7, IRF9, NFKBIA, IL28A/IL28B, IL29, IL28RA, IL10RB, IFNAR2, and STAT1) that promote antiviral state and 4 genes (SOCS1, SOCS3, Zc3h12a, and A20) that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21739451
DOI: 10.1002/jmv.22158

Genes

ISG15
SOCS1
IFNAR2
NFKBIA
OAS1
SOCS3
STAT1
TLR8

Provenance

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Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.PMID 21739451Read ↗

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