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Article

The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2010

Crist Richard C, Roth Jacquelyn J, Baran Amy A, McEntee Benjamin J, Siracusa Linda D, Buchberg Arthur M

Abstract excerpt

The adenomatous polyposis coli (APC) gene is known to act as a tumor suppressor gene in both sporadic and hereditary colorectal cancer by negatively regulating WNT signaling. Familial adenomatous polyposis (FAP) patients develop intestinal polyps due to the presence of a single germline mutation in APC. The severity of the FAP phenotype is a function of the position of the APC mutation, indicating a complex role...

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Topics

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Share to Adenomatous Polyposis Coli
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Armadillo Domain Proteins

Share to beta-Galactosidase

Share to Gene Fusion

Share to Genes, APC

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Source

Open in PubMed Open full text

Identifiers

PMID: 20886217
DOI: 10.1007/s00335-010-9288-0
PMCID: PMC3025611

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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