Article
Olfactomedin 4 deletion induces colon adenocarcinoma in ApcMin/+ mice.
Oncogene - 6 Oct 2016
Liu W, Li H, Hong S-H, Piszczek G P, Chen W, Rodgers G P
Abstract excerpt
Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 (OLFM4) has emerged as an intestinal stem-cell marker, but its biological function in the...
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