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Article

Mechanisms of APC-driven tumorigenesis: lessons from mouse models.

Cytogenetics and cell genetics - 1 Jan 1999

Fodde R, Smits R, Hofland N, Kielman M, Meera Khan P

Abstract excerpt

Colorectal cancer still represents one of the most common causes of morbidity and mortality among Western populations. The adenomatous polyposis coli (APC) gene, originally identified as the gene responsible for familial adenomatous polyposis (FAP), an inherited predisposition to multiple colorectal tumors, is now considered as the true "gatekeeper" of colonic epithelial proliferation. It is mutated in the vast...

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Identifiers

PMID: 10545699
DOI: 10.1159/000015361

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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