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Article

The adenomatous polyposis coli (APC) tumor suppressor.

Biochimica et biophysica acta - 7 Jun 1997

Polakis P

Abstract excerpt

Defects in the APC gene are inarguably linked to the progression of colon cancers that arise both sporadically and through the transmission of germline mutations. Genetic evidence from humans and mouse models suggest that APC is a classic tumor suppressor in that both alleles likely require inactivation for tumor growth to ensue. Nearly all of the mutations, germline and somatic, result in premature termination...

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Source

Identifiers

PMID: 9196022
DOI: 10.1016/s0304-419x(97)00008-5

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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