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Article

Biology of the adenomatous polyposis coli tumor suppressor.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2000

Goss K H, Groden J

Abstract excerpt

The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an inherited syndrome of colon cancer predisposition known as familial adenomatous polyposis coli (FAP). Mutation of APC is also found in 80% of all colorectal adenomas and carcinomas and is one of the earliest mutations in colon cancer progression. Similar to other tumor suppressor genes, both APC alleles are inactivated by...

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Source

Identifiers

PMID: 10784639
DOI: 10.1200/JCO.2000.18.9.1967

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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