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Article

The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.

American journal of physiology. Gastrointestinal and liver physiology - 1 Nov 2010

Lin Songbai, Lee Sei-Jung, Shim Hyunsuk, Chun Jerold, Yun C Chris

Abstract excerpt

Lysophosphatidic acid (LPA) is a lipid mediator that mediates several effects that promote cancer progress. The LPA receptor type 2 (LPA(2)) expression is often elevated in several types of cancers, including colorectal cancer (CRC). In this study, we investigated the role of LPA(2) in the develo...

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Source

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Identifiers

PMID: 20724530
DOI: 10.1152/ajpgi.00321.2010
PMCID: PMC2993170

Genes

LPA
KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20724530-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.PMID 20724530Read ↗

Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.Semantic proximity Read ↗

Liver fatty acid-binding protein (L-Fabp) modifies intestinal fatty acid composition and adenoma formation in ApcMin/+ mice.Semantic proximity Read ↗

Period 2 mutation accelerates ApcMin/+ tumorigenesis.Semantic proximity Read ↗

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.Semantic proximity Read ↗

Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Fas/CD95 Deficiency in ApcMin/+ Mice Increases Intestinal Tumor BurdenSemantic proximity Read ↗

The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.Semantic proximity Read ↗

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formationSemantic proximity Read ↗

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse.Semantic proximity Read ↗

Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene.Semantic proximity Read ↗

Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.Semantic proximity Read ↗

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