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Article

APC and its modifiers in colon cancer.

Advances in experimental medicine and biology - 1 Jan 2009

Kwong Lawrence N, Dove William F

Abstract excerpt

Colon cancer closely follows the paradigm of a single "gatekeeper gene." Mutations inactivating the APC (adenomatous polyposis coli) gene are found in approximately 80% of all human colon tumors and heterozygosity for such mutations produces an autosomal dominant colon cancer predisposition in humans and in murine models. However, this tight association between a single genotype and phenotype belies a complex...

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Identifiers

PMID: 19928355
DOI: 10.1007/978-1-4419-1145-2_8
PMCID: PMC3754875

Genes

APC

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