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Article

APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.

Developmental biology - 15 Jun 2013

Wang Chenhui, Zhao Rui, Huang Pin, Yang Fu, Quan Zhenghui, Xu Na, Xi Rongwen

Abstract excerpt

Adenomatous polyposis coli (APC) and K-ras are the two most frequently mutated genes found in human colorectal cancers. In human colorectal cancers, Wnt signaling activation after the loss of APC is hypothesized to be the key event for adenoma initiation, whereas additional mutations such as Ras activation are required for the progression from adenoma to carcinoma. However, accumulating data have led to...

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PMID: 23570874
DOI: 10.1016/j.ydbio.2013.03.020

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APC

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