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Article

Complete deletion of Apc results in severe polyposis in mice.

Oncogene - 25 Mar 2010

Cheung A F, Carter A M, Kostova K K, Woodruff J F, Crowley D, Bronson R T, Haigis K M, Jacks T

Abstract excerpt

The adenomatous polyposis coli (APC) gene product is mutated in the vast majority of human colorectal cancers. APC negatively regulates the WNT pathway by aiding in the degradation of beta-catenin, which is the transcription factor activated downstream of WNT signaling. APC mutations result in beta-catenin stabilization and constitutive WNT pathway activation, leading to aberrant cellular proliferation. APC...

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Identifiers

PMID: 20010873
DOI: 10.1038/onc.2009.457
PMCID: PMC2990498

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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