Article

β2-Chimaerin Deficiency Favors Polyp Growth in the Colon of Apc<sup>Min/+</sup> Mice

2025-01-02

Abstract excerpt

A Rho-GTPases are pivotal regulators of key cellular processes implicated in colorectal cancer (CRC) progression, yet the roles of their regulatory proteins, particularly GTPase-activating proteins (GAPs), remain poorly understood. This study focuses on β2-chimaerin, a Rac1-specific GAP, in Apc-driven tumorigenesis using the ApcMin/+ mouse model. We demonstrate that β2-chimaerin deficiency selectively promotes the...

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Literature Corpus work: 79e5da2b-f6a3-5a0a-8250-1fc5efad83ee
DOI: 10.20944/preprints202412.2563.v1

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