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Article

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.

Cancer research - 15 Oct 2007

Hinoi Takao, Akyol Aytekin, Theisen Brian K, Ferguson David O, Greenson Joel K, Williams Bart O, Cho Kathleen R, Fearon Eric R

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis. Existing mouse intestinal tumor models display mainly small intestinal lesions and carcinomas are rare. We defined human CDX2 sequences conferring colon epithelium-preferential transgene expression in the adult mouse. Mice carrying a CDX2P-NLS Cre recombinase transgene and a loxP-targeted Apc allele developed mainly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17942902
DOI: 10.1158/0008-5472.CAN-07-2735

Genes

APC
CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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