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Article

Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.

Medical molecular morphology - 1 Jun 2007

Senda Takao, Iizuka-Kogo Akiko, Onouchi Takanori, Shimomura Atsushi

Abstract excerpt

The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis and in most sporadic colorectal tumors. During both embryonic and postnatal periods, APC is widely expressed in a variety of tissues, including the brain and gastrointestinal tract. The APC gene product (APC) is a large multidomain protein consisting of 2843 amino acids. APC downregulates the Wnt signaling pathway through its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17572842
DOI: 10.1007/s00795-006-0352-5

Genes

APC
IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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