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Article

Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the <i>Apc</i> Gene

3 Oct 1997

Abstract excerpt

Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene. With the use of a conditional gene targeting system, a mouse model of FAP was created that circumvents the embryonic lethality of Apc deficiency and directs Apc inactivation specifically to the colorectal epithelium. loxP sites...

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PMID: 9311916
DOI: 10.1126/science.278.5335.120

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Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the <i>Apc</i> GenePMID 9311916Read ↗

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