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Article

Beneficial metabolic effects caused by persistent activation of beta-cell M3 muscarinic acetylcholine receptors in transgenic mice.

Endocrinology - 1 Nov 2010

Gautam Dinesh, Ruiz de Azua Inigo, Li Jian Hua, Guettier Jean-Marc, Heard Thomas, Cui Yinghong, Lu Huiyan, Jou William, Gavrilova Oksana, Zawalich Walter S, Wess Jürgen

Abstract excerpt

Previous studies have shown that β-cell M(3) muscarinic acetylcholine receptors (M3Rs) play a key role in maintaining blood glucose homeostasis by enhancing glucose-dependent insulin release. In this study, we tested the hypothesis that long-term, persistent activation of β-cell M3Rs can improve glucose tolerance and ameliorate the metabolic deficits associated with the consumption of a high-fat diet. To achieve...

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Identifiers

PMID: 20843999
DOI: 10.1210/en.2010-0519
PMCID: PMC2954720

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Source receipt: pubmed, retrieved 7 Sept 2026.

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