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Article

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.

Metabolism: clinical and experimental - 1 Oct 2004

Pearce Nigel J, Arch Jonathan R S, Clapham John C, Coghlan Matthew P, Corcoran Stacey L, Lister Carolyn A, Llano Andrea, Moore Gary B, Murphy Gregory J, Smith Stephen A, Taylor Colleen M, Yates John W, Morrison Alastair D, Harper Alexander J, Roxbee-Cox Lynne, Abuin Alejandro, Wargent Ed, Holder Julie C

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen synthase activity and insulin-stimulated glucose disposal. To explore this relationship, we have produced transgenic mice that overexpress...

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Identifiers

PMID: 15375789
DOI: 10.1016/j.metabol.2004.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15375789-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.PMID 15375789Read ↗

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