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Article

Constitutive (pro)insulin release from pancreas of transgenic mice expressing monomeric insulin.

Endocrinology - 1 Jun 1995

Ma Y H, Lores P, Wang J, Jami J, Grodsky G M

Abstract excerpt

To evaluate the role of protein aggregation and calcium in the sorting of insulin for regulated vs. constitutive release from the intact pancreas, we targeted the expression of a monomeric mutant form of human (pro)insulin (B9/B27) to the pancreatic beta-cells of transgenic mice. This mutant insulin does not form dimers or hexamers, but can aggregate at high concentration in the presence of calcium. A homozygous...

Topics

Animals
Base Sequence
DNA Probes
Gene Expression
Humans
In Vitro Techniques
Islets of Langerhans
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Transgenic
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Perfusion

Proinsulin

Protein Conformation

RNA, Messenger

Source

Identifiers

PMID: 7750485
DOI: 10.1210/endo.136.6.7750485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7750485-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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