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Article

Constitutive (pro)insulin release from pancreas of transgenic mice expressing monomeric insulin.

Endocrinology - 1 Jun 1995

Ma Y H, Lores P, Wang J, Jami J, Grodsky G M

Abstract excerpt

To evaluate the role of protein aggregation and calcium in the sorting of insulin for regulated vs. constitutive release from the intact pancreas, we targeted the expression of a monomeric mutant form of human (pro)insulin (B9/B27) to the pancreatic beta-cells of transgenic mice. This mutant insulin does not form dimers or hexamers, but can aggregate at high concentration in the presence of calcium. A homozygous...

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PMID: 7750485
DOI: 10.1210/endo.136.6.7750485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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