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Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.

Diabetes - 1 Aug 2003

Winzell Maria Sörhede, Svensson Håkan, Enerbäck Sven, Ravnskjaer Kim, Mandrup Susanne, Esser Victoria, Arner Peter, Alves-Guerra Marie-Clotilde, Miroux Bruno, Sundler Frank, Ahrén Bo, Holm Cecilia

Abstract excerpt

Lipid perturbations associated with triglyceride overstorage in beta-cells impair insulin secretion, a process termed lipotoxicity. To assess the role of hormone-sensitive lipase, which is expressed and enzymatically active in beta-cells, in the development of lipotoxicity, we generated transgenic mice overexpressing hormone-sensitive lipase specifically in beta-cells. Transgenic mice developed glucose...

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PMID: 12882923
DOI: 10.2337/diabetes.52.8.2057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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