Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

doi:10.1096/fj.14-262782

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Article

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2015

Kinross Kathryn M, Montgomery Karen G, Mangiafico Salvatore P, Hare Lauren M, Kleinschmidt Margarete, Bywater Megan J, Poulton Ingrid J, Vrahnas Christina, Henneicke Holger, Malaterre Jordane, Waring Paul M, Cullinane Carleen, Sims Natalie A, McArthur Grant A, Andrikopoulos Sofianos, Phillips Wayne A

Abstract excerpt

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most common mutations found in human cancer and have also recently been implicated in a range of overgrowth syndromes in humans. We have used a novel inducible "exon-switch" approach to knock in the constitutively active Pik3ca(H1047R) mutation into the endogenous Pik3ca gene of the mouse. Ubiquitous expression of the...

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PMID: 25550458
DOI: 10.1096/fj.14-262782

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