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Article

In Vivo Monitoring of Pancreatic β-Cells in a Transgenic Mouse Model

1 Apr 2006

Abstract excerpt

We generated a transgenic mouse model (RIP-luc) for the in vivo monitoring of pancreatic islet mass and function in response to metabolic disease. Using the rat insulin promoter fused to firefly luciferase, and noninvasive technology to detect luciferase activity, we tracked changes in reporter signal during metabolic disease states and correlated the changes in luciferase signal with metabolic status of the...

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PMID: 16954020
DOI: 10.2310/7290.2006.00007

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