Article
Targeted disruption of the beta 3-adrenergic receptor gene.
The Journal of biological chemistry - 8 Dec 1995
Susulic V S, Frederich R C, Lawitts J, Tozzo E, Kahn B B, Harper M E, Himms-Hagen J, Flier J S, Lowell B B
Abstract excerpt
beta 3-Adrenergic receptors (beta 3-ARs) are expressed predominantly in white and brown adipose tissue, and beta 3-selective agonists are potential anti-obesity drugs. However, the role of beta 3-ARs in normal physiology is unknown. To address this issue, homologous recombination was used to gene...
Topics
- Adenylyl Cyclases
- Adipose Tissue
- Animals
- Fatty Acids, Nonesterified
- Female
- Gene Targeting
- Lipolysis
- Male
- Mice
- Phenotype
- RNA, Messenger
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, beta-1
- Receptors, Adrenergic, beta-2
- Receptors, Adrenergic, beta-3