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Article

Targeted disruption of the beta 3-adrenergic receptor gene.

The Journal of biological chemistry - 8 Dec 1995

Susulic V S, Frederich R C, Lawitts J, Tozzo E, Kahn B B, Harper M E, Himms-Hagen J, Flier J S, Lowell B B

Abstract excerpt

beta 3-Adrenergic receptors (beta 3-ARs) are expressed predominantly in white and brown adipose tissue, and beta 3-selective agonists are potential anti-obesity drugs. However, the role of beta 3-ARs in normal physiology is unknown. To address this issue, homologous recombination was used to generate mice that lack beta 3-ARs. This was accomplished by direct injection of a DNA-targeting construct into mouse...

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Identifiers

PMID: 7493988
DOI: 10.1074/jbc.270.49.29483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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