Article
Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review.
Journal of receptor and signal transduction research - 1 Jan 2008
Gautam Dinesh, Jeon Jongrye, Li Jian Hua, Han Sung-Jun, Hamdan Fadi F, Cui Yinghong, Lu Huiyan, Deng Chuxia, Gavrilova Oksana, Wess Jürgen
Abstract excerpt
The M(3) muscarinic acetylcholine (ACh) receptor (M(3) mAChR) is expressed in many central and peripheral tissues. It is a prototypic member of the superfamily of G protein-coupled receptors and preferentially activates G proteins of the G(q) family. Recent studies involving the use of newly generated mAChR mutant mice have revealed that the M(3) mAChR plays a key role in regulating many important metabolic...
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