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Article

Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice.

The Journal of biological chemistry - 25 Jul 2003

Sasaki Akinori, Hata Keiko, Suzuki Susumu, Sawada Masashi, Wada Tadashi, Yamaguchi Kazunori, Obinata Masuo, Tateno Hiroo, Suzuki Hiroshi, Miyagi Taeko

Abstract excerpt

Plasma membrane-associated sialidase is a key enzyme for ganglioside hydrolysis, thereby playing crucial roles in regulation of cell surface functions. Here we demonstrate that mice overexpressing the human ortholog (NEU3) develop diabetic phenotype by 18-22 weeks associated with hyperinsulinemia, islet hyperplasia, and increased beta-cell mass. As compared with the wild type, insulin-stimulated phosphorylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12730204
DOI: 10.1074/jbc.M212200200

Genes

NEU3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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