Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

Cell metabolism - 1 Jun 2006

Gautam Dinesh, Han Sung-Jun, Hamdan Fadi F, Jeon Jongrye, Li Bo, Li Jian Hua, Cui Yinghong, Mears David, Lu Huiyan, Deng Chuxia, Heard Thomas, Wess Jürgen

Abstract excerpt

One of the hallmarks of type 2 diabetes is that pancreatic beta cells fail to release sufficient amounts of insulin in the presence of elevated blood glucose levels. Insulin secretion is modulated by many hormones and neurotransmitters including acetylcholine, the major neurotransmitter of the peripheral parasympathetic nervous system. The physiological role of muscarinic acetylcholine receptors expressed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glucose Intolerance
Share to Glucose Tolerance Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperinsulinism

Share to Hypoglycemia

Share to Inositol Phosphates

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to Receptor, Muscarinic M3

Source

Identifiers

PMID: 16753580
DOI: 10.1016/j.cmet.2006.04.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.PMID 16753580Read ↗

Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications.Semantic proximity Read ↗

Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors.Semantic proximity Read ↗

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review.Semantic proximity Read ↗

Beneficial metabolic effects caused by persistent activation of beta-cell M3 muscarinic acetylcholine receptors in transgenic mice.Semantic proximity Read ↗

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetesSemantic proximity Read ↗

Cholinergic augmentation of insulin release requires ankyrin-B.Semantic proximity Read ↗

Bombesin receptor subtype-3 modulates plasma insulin concentration.Semantic proximity Read ↗

Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice.Semantic proximity Read ↗

Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.Semantic proximity Read ↗

M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.Semantic proximity Read ↗

Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistanceSemantic proximity Read ↗

Insulin secretory deficiency and glucose intolerance in Rab3A null mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.