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Article

Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications.

Trends in endocrinology and metabolism: TEM - 1 Feb 2011

Ruiz de Azua Inigo, Gautam Dinesh, Guettier Jean-Marc, Wess Jürgen

Abstract excerpt

Impaired function of pancreatic β-cells is one of the hallmarks of type 2 diabetes. β-cell function is regulated by the activity of many hormones and neurotransmitters, which bind to specific cell surface receptors. The M(3) muscarinic acetylcholine receptor (M3R) belongs to the superfamily of G protein-coupled receptors and, following ligand dependent activation, selectively activates G proteins of the G(q/11)...

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Identifiers

PMID: 21106385
DOI: 10.1016/j.tem.2010.10.004
PMCID: PMC3053051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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