Article
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010
Hong L Elliot, Hodgkinson Colin A, Yang Yihong, Sampath Hemalatha, Ross Thomas J, Buchholz Brittany, Salmeron Betty Jo, Srivastava Vibhuti, Thaker Gunvant K, Goldman David, Stein Elliot A
Abstract excerpt
Whole-genome searches have identified nicotinic acetylcholine receptor alpha5-alpha3-beta4 subunit gene variants that are associated with smoking. How genes support this addictive and high-risk behavior through their expression in the brain remains poorly understood. Here we show that a key alpha5 gene variant Asp398Asn is associated with a dorsal anterior cingulate-ventral striatum/extended amygdala circuit,...
Topics
- 3' Untranslated Regions
- Adolescent
- Adult
- Amygdala
- Basal Ganglia
- Brain Mapping
- Female
- Gene Frequency
- Genotype
- Gyrus Cinguli