The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.

doi:10.1038/npp.2017.121

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The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2018

Cao Hengyi, Harneit Anais, Walter Henrik, Erk Susanne, Braun Urs, Moessnang Carolin, Geiger Lena S, Zang Zhenxiang, Mohnke Sebastian, Heinz Andreas, Romanczuk-Seiferth Nina, Mühleisen Thomas, Mattheisen Manuel, Witt Stephanie H, Cichon Sven, Nöthen Markus M, Rietschel Marcella, Meyer-Lindenberg Andreas, Tost Heike

Abstract excerpt

The serotonin transporter-linked polymorphic region 5-HTTLPR is a key genetic regulator of 5-HTT expression in the human brain where the short allele S has been implicated in emotion dysregulation. However, the neural mechanism underlying the association between this variant and emotion processing is still unclear. Earlier studies suggested an effect of 5-HTTLPR on amygdala activation during emotional face...

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PMID: 28589968
DOI: 10.1038/npp.2017.121
PMCID: PMC5729553

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