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A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression

2026-01-14

Abstract excerpt

<h4>SUMMARY</h4> Stress exposure is a major risk factor for psychopathology, yet how stress mediators shape long-term psychiatric vulnerability in humans remains unclear. Glucocorticoids, central effectors of the stress response, regulate gene expression through tissue-specific transcriptional programs, suggesting that glucocorticoid-responsive networks may shape sensitivity to adversity. Using RNA-sequencing fol...

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Literature Corpus work
51c0599f-c942-549f-a685-0707c6b21e95
DOI
10.64898/2026.01.14.699350
Open publication

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A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depressionDOI 10.64898/2026.01.14.699350
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