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Article

From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Nov 2012

Ware Jennifer J, van den Bree Marianne, Munafò Marcus R

Abstract excerpt

INTRODUCTION: The nicotinic acetylcholine receptor (nAChR) gene cluster CHRNA5-A3-B4 on chromosome 15 has been the subject of a considerable body of research over recent years. Two highly correlated single nucleotide polymorphisms (SNPs) within this region--rs16969968 in CHRNA5 and rs1051730 in CHRNA3--have generated particular interest. METHODS: We reviewed the literature relating to SNPs rs16969968 and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22544838
DOI: 10.1093/ntr/nts106
PMCID: PMC3482013

Genes

CHRNA5
CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.PMID 22544838Read ↗

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Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.Semantic proximity Read ↗

The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to TherapeuticsSemantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

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